Methylamine → Orf 17583

HRID 1075046Notes

Reaction equation

HRID 1075046 reaction equation
CN.CO[C:5]1[C:9]([NH:10][CH3:11])=[N:8][S:7](=[O:12])[N:6]=1.[CH3:13][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:24][CH2:25][NH2:26])=[CH:19][CH:18]=1)[CH3:15]>>[CH3:15][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:24][CH2:25][NH:26][C:5]2[C:9]([NH:10][CH3:11])=[N:8][S:7](=[O:12])[N:6]=2)=[CH:19][CH:18]=1)[CH3:13]

Participants

4

Reactant 3

HCID 6329MethylamineHCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 200307843-Methoxy-4-methylamino-1,2,5-thiadiazole 1-oxide

Product 1

HCID 5486884Orf 17583

Procedure

Reaction of a methanolic solution of 3,4-dimethoxy-1,2,5-thiadizole 1-oxide [prepared in Example 4, Step A] with one equivalent of methylamine and treatment of the resultant 3-methoxy-4-methylamino-1,2,5-thiadiazole 1-oxide with one equivalent of 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine yields the title compound, which is identical to the product prepared in Example 18.

Sources & evidence

ORD record
ord-1c15b7e638fa4f588dd3bd2c30f613ab
Source dataset
uspto-grants-1983_07
Patent number
US04394508

Reaction notes

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