Methylamine → HCID 178482517, compound

HRID 1075065Notes

Reaction equation

HRID 1075065 reaction equation
COC1C(OC)=NS(=O)(=O)N=1.CN.CO[C:16]1[C:20]([NH:21][CH3:22])=[N:19][S:18](=[O:24])(=[O:23])[N:17]=1.[CH3:25][N:26]([CH2:28][C:29]1[S:30][CH:31]=[C:32]([CH2:34][S:35][CH2:36][CH2:37][NH2:38])[N:33]=1)[CH3:27]>>[CH3:27][N:26]([CH2:28][C:29]1[S:30][CH:31]=[C:32]([CH2:34][S:35][CH2:36][CH2:37][NH:38][C:16]2[C:20]([NH:21][CH3:22])=[N:19][S:18](=[O:24])(=[O:23])[N:17]=2)[N:33]=1)[CH3:25]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 109773182-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazoleHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 178482530HCID 178482530, compound

Product 1

HCID 178482517HCID 178482517, compound

Procedure

Reaction of a methanolic suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide with one equivalent of methylamine and treatment of the resultant 3-methoxy-4-methylamino-1,2,5-thiadiazole 1,1-dioxide with one equivalent of 2-[(2-dimethylaminomethyl-4-thiazolyl)methylthio]ethylamine [prepared in Example 33, Step E], produces the title compound which is identical to the product prepared in Example 33.

Sources & evidence

ORD record
ord-912cb678c69f400ca922c8d650dc7829
Source dataset
uspto-grants-1983_07
Patent number
US04394508

Reaction notes

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