Acetone → 2(1H)-Pyrimidinone, 5-chloro-1-methyl-

HRID 1075139Notes

Reaction equation

[K].[Cl:2][C:3]1[CH:4]=[N:5][C:6](=[O:9])[NH:7][CH:8]=1.[CH3:10]C(C)=O>>[CH3:10][N:5]1[CH:4]=[C:3]([Cl:2])[CH:8]=[N:7][C:6]1=[O:9]

Participants

Reactant 3

HCID 180Acetone

HCID 1085785-Chloro-2(1H)-pyrimidinone

HCID 5462222Potassium

Product 1

HCID 1439722(1H)-Pyrimidinone, 5-chloro-1-methyl-Yield 50%

Procedure

1-Methyl-5-chloropyrimid-2-one was prepared as above from the potassium salt of 5-chloropyrimid-2-one (prepared as described in Crosby, G. D. and Berthold, V. R. J. Org. Chem. 25 (1960) 1916) in 50% yield, m.p. 210° C. (acetone). (Found: C, 41.61; H, 3.65; Calc. for C5H5ClN2O: C, 41.54; H, 3.48)

Sources & evidence

ORD record: ord-26e9b4a39b3449e7ae3916af4b6343e8
Source dataset: uspto-grants-1983_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04395406

Reaction notes

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