HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 5-Chloro-1-methylpyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 5-Chloro-2(1H)-pyrimidinone | HCID 108578 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Product | 5-Chloro-1-methylpyrimidin-2(1H)-one | HCID 143972 | 50% |
Reaction Steps
1-Methyl-5-chloropyrimid-2-one was prepared as above from the potassium salt of 5-chloropyrimid-2-one (prepared as described in Crosby, G. D. and Berthold, V. R. J. Org. Chem. 25 (1960) 1916) in 50% yield, m.p. 210° C. (acetone). (Found: C, 41.61; H, 3.65; Calc. for C5H5ClN2O: C, 41.54; H, 3.48)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04395406 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-26e9b4a39b3449e7ae3916af4b6343e8 |
| Source note | uspto-grants-1983_07 |