Methyl iodide → HCID 20494304, compound

HRID 1075147Notes

Reaction equation

HRID 1075147 reaction equation
[CH3:1][N:2]([CH3:13])[CH2:3][CH2:4][N:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[N:7][C:6]1=[O:12].[CH3:14][I:15]>C(#N)C>[I-:15].[CH3:1][N+:2]([CH3:14])([CH3:13])[CH2:3][CH2:4][N:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[N:7][C:6]1=[O:12]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20494277HCID 20494277, compound

Product 1

HCID 20494304HCID 20494304, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1-(2-Dimethylaminoethyl)-5-chloropyrimid-2-one (0.004 mol) and methyl iodide (0.006 mol) were dissolved in acetonitrile (20 ml) and the reaction mixture was stirred at room temperature for 6 h. The precipitate was then collected, washed with ether and recrystallized by dissolving in boiling isopropanol (50 ml) to which water (in all 14 ml) was added dropwise, until dissolution was complete; yield 50%, m.p. 235° C. (decomp.). (Found: C, 31.34; H, 4.48. Calc. for C9H15ClIN3O: C, 31.46; H, 4.40).

Workup

  1. customThe precipitate was then collected
  2. washwashed with ether
  3. customrecrystallized
  4. dissolutionby dissolving
  5. additionwas added dropwise, until dissolution

Sources & evidence

ORD record
ord-5ed42576222d4e6e872559addecef5f6
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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