反应详情

The sodium salt of 5-fluoropyrimid-2-one (0.01 mol) was dissolved in methanol (100 ml) and allyl bromide (0.015 mol) added gradually at room temperature and the reaction allowed to proceed until neutral pH had been reached. The reaction mixture was then concentrated at reduced pressure and the residue extracted with chloroform (100 ml). The chloroform solution was washed with water (2×5 ml) and dried before evaporation; Yield 48%, m.p. 88°-90° C. after recrystallisation from acetone: (Found: C, 55.10; H, 4.80. Calc. for C7H7FN2O: C, 54.56; H, 4.58.

1. concentrationThe reaction mixture was then concentrated at reduced pressure
2. extractionthe residue extracted with chloroform (100 ml)
3. washThe chloroform solution was washed with water (2×5 ml)
4. customdried before evaporation
5. customYield 48%, m.p. 88°-90° C. after recrystallisation from acetone