反应详情

4-Methylthiopyrimid-2-one (prepared as described in Wheller, L. H. and Johnson, B. T. J. Amer. Chem. Soc. 42 (1909) (30), (0.01 mol) was dissolved at ca. 80° C. in acetic acid (30 ml) containing 2% acetic anhydride. The temperature was lowered to ca. 55° C. and N-bromosuccinimide (0.013 mol) added and the reaction mixture stirred at this temperature for 40 min. Ice-cold water (150 ml) containing a little sodium bisulphite was then added and the precipitated collected and recrystallised from water; yield 28%, m.p. 260° C.;

1. customwas lowered to ca. 55° C.
2. additionwas then added
3. customthe precipitated collected
4. customrecrystallised from water