Methylurea → 2(1H)-Pyrimidinone, 5-chloro-1-methyl-

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Reaction Steps

A mixture of 2-chloro-1,1,3,3-tetramethoxypropane (0.05 mol), N-methylurea (0.04 mol) in 10 N HCl (10 ml) in ethanol (100 ml) was allowed to stand at room temperature for 4 days. The reaction mixture was then evaporated, the residue dissolved in water (100 ml) and the pH of the solution adjusted to 8 by means of Na2CO3. The mixture was then extracted with chloroform (4×30 ml) and the dried (Na2SO4) extracts evaporated. The residue was recrystallised from acetone; yield 20%. The physical data for the product was identical to those measured for the compound as prepared by the method of Example 2.

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