Methylurea → 2(1H)-Pyrimidinone, 5-chloro-1-methyl-

A mixture of 2-chloro-1,1,3,3-tetramethoxypropane (0.05 mol), N-methylurea (0.04 mol) in 10 N HCl (10 ml) in ethanol (100 ml) was allowed to stand at room temperature for 4 days. The reaction mixture was then evaporated, the residue dissolved in water (100 ml) and the pH of the solution adjusted to 8 by means of Na2CO3. The mixture was then extracted with chloroform (4×30 ml) and the dried (Na2SO4) extracts evaporated. The residue was recrystallised from acetone; yield 20%. The physical data for the product was identical to those measured for the compound as prepared by the method of Example 2.

1. customThe reaction mixture was then evaporated
2. dissolutionthe residue dissolved in water (100 ml)
3. extractionThe mixture was then extracted with chloroform (4×30 ml)
4. dry with materialthe dried (Na2SO4)
5. customextracts evaporated
6. customThe residue was recrystallised from acetone
7. customas prepared by the method of Example 2

ORD record

ord-4f491b84dfeb4fd7ad8608679f58b141

Source dataset

uspto-grants-1983_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04395406