1,3-Dichloropropane → HCID 53876416, compound

HRID 1075176Notes

Reaction equation

HRID 1075176 reaction equation
[K].[Cl:2][C:3]1[CH:4]=[N:5][C:6](=[O:9])[NH:7][CH:8]=1.[Cl:10][CH2:11][CH2:12][CH2:13]Cl>CN(C)C=O>[Cl:10][CH:11]=[CH:12][CH2:13][N:5]1[CH:4]=[C:3]([Cl:2])[CH:8]=[N:7][C:6]1=[O:9]

Participants

5

Reactant 3

HCID 88811,3-DichloropropaneHCID 1085785-Chloro-2(1H)-pyrimidinoneHCID 5462222Potassium

Product 1

HCID 53876416HCID 53876416, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of the potassium salt of 5-chloropyrimid-2-one (0.01 mol) and 1.3-dichloropropane (0.02 mol) in dimethylformamide (50 ml) was heated at 60° C. for 8 h. The reaction mixture was then evaporated (1 mm Hg) and the residue dissolved in chloroform (80 ml). This solution was washed with 1 N NaOH (2 ml) and water before drying and evaporation; yield 60%, m.p. 102°-104° C. (benzene/ligroin). (Found: C, 41.83; H, 3.02. Calc. for C7H6ClN2O: C, 41.01; H, 2.95).

Workup

  1. customThe reaction mixture was then evaporated (1 mm Hg)
  2. dissolutionthe residue dissolved in chloroform (80 ml)
  3. washThis solution was washed with 1 N NaOH (2 ml) and water
  4. custombefore drying
  5. customevaporation

Sources & evidence

ORD record
ord-82b57aa6726e47ad99e6b3466dd9ded2
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

Loading…