Dimethylamine → HCID 12785882, compound

HRID 1075214Notes

Reaction equation

HRID 1075214 reaction equation
[CH3:1][NH:2][CH3:3].[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]=[C:13]([NH:15][O:16][C:17](=[O:25])[NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:12]([O:26][C:27](OC3C=CC=CC=3)=[O:28])[N:11]=[C:10]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:9]=2[CH:42]=1.O>CO>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]=[C:13]([NH:15][O:16][C:17](=[O:25])[NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:12]([O:26][C:27](=[O:28])[N:2]([CH3:3])[CH3:1])[N:11]=[C:10]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:9]=2[CH:42]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 962WaterHCID 12785886HCID 12785886, compound

Product 1

HCID 12785882HCID 12785882, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

5 ml of a solution of dimethylamine in methanol (content 30 g of dimethylamine in 100 ml) are added to 0.5 g of 7-chloro-5-phenyl-2-phenylcarbamoyloxyamino-3-phenyloxycarbonyloxy-3H-1,4-benzodiazepine in 10 ml of methanol, whilst stirring. The mixture is stirred for 5 hours at room temperature and water is added to it; the residue is filtered off and dried.

Workup

  1. stirringThe mixture is stirred for 5 hours at room temperature
  2. filtrationthe residue is filtered off
  3. customdried

Sources & evidence

ORD record
ord-e8f8110cd3784858a1c24921bd403de6
Source dataset
uspto-grants-1983_07
Patent number
US04395409

Reaction notes

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