HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Aminohexanoic Acid → 6-Maleimidohexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Aminohexanoic Acid | HCID 564 | — |
| Reactant | Maleic Anhydride | HCID 7923 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Maleimidohexanoic acid | HCID 573683 | — |
Reaction Steps
The symmetrical anhydride of 6-Maleimidocaproic acid (Compound 24, FIG. 5) was prepared by the reaction of maleic anhydride and ε-Amino-n-caproic acid in the presence of acetic acid to give 6-Maleimidocaproic acid (Compound 23) which was then converted to Compound 24 using dicyclohexyl carbodiimide (DCCI).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05900237 |
| Source dataset | uspto-grants-1999_05 |
| ORD ID | ord-8380e9c22033478e94ea68707f91a745 |
| Source note | uspto-grants-1999_05 |