反应详情

To a suspension of 4-fluoro-3-nitroaniline (20g, 0.13mol) in toluene (200mi) is added 2,5-dimethoxytetrahydrofuran (33ml, 0.26mol) and a catalytic amount of pTSA. The mixture is refluxed for 2.5 hours. After cooling the solvent is removed by evaporation and the residue is purified by column chromatography on silica gel using a mixture of ethyl acetate and petroleum ether (1:1) as the eluent. Yield: 23.1g (87%). Mp 79-81° C.

1. temperatureThe mixture is refluxed for 2.5 hours
2. temperatureAfter cooling the solvent
3. customis removed by evaporation
4. customthe residue is purified by column chromatography on silica gel using
5. additiona mixture of ethyl acetate and petroleum ether (1:1) as the eluent