4-Bromophenyl isocyanate → HCID 44212575, compound

HRID 1075539Notes

Reaction equation

HRID 1075539 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[C:14]([N:20]3[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]3)[CH:15]=2)=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 756094-Bromophenyl isocyanateHCID 103311014-Methoxy-3-(4-methylpiperazin-1-yl)aniline

Product 1

HCID 44212575HCID 44212575, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4-bromophenyl isocyanate (0.179 g, 0.905 mmol) and 4-methoxy-3-(4-methyl-1-piperazinyl)benzeneamine (EP 0 533 267 A1) (0.200 g, 0.905 mmol) in toluene were stirred together at room temperature. After 24 h, the resultant precipitate was filtered off, washed with petrol and dried in vacuo to give the title compound as a white solid (0.265 g, 70%). m.pt 199-201° C.

Workup

  1. filtrationthe resultant precipitate was filtered off
  2. washwashed with petrol
  3. customdried in vacuo

Sources & evidence

ORD record
ord-d277323a3a1a47fcb5b38d7f556388bf
Source dataset
uspto-grants-1999_05
Patent number
US05905080

Reaction notes

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