Hydrochloric Acid → HCID 178480206, compound

HRID 1075573Notes

Reaction equation

HRID 1075573 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:9]=[N:10][C:11]3[C:12]=2[NH:13][C:14]([C:17]([O:19]C)=[O:18])=[CH:15][CH:16]=3)[CH2:4][CH2:3]1.[ClH:21]>>[ClH:21].[ClH:21].[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([C:8]2[CH:9]=[N:10][C:11]3[C:12]=2[NH:13][C:14]([C:17]([OH:19])=[O:18])=[CH:15][CH:16]=3)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178497321HCID 178497321, compound

Product 1

HCID 178480206HCID 178480206, compoundYield 87%

Procedure

A solution of 0.125 gm (0.46 mMol) methyl 3-(1-methyl-piperidin-4-yl)pyrrolo[3,2-b]pyridine-5-carboxylate in 30 mL 1N hydrochloric acid was heated at reflux for 18 hours. The reaction mixture was concentrated under reduced pressure to provide 0.10 gm (87%) title compound.

Workup

  1. temperatureat reflux for 18 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-44c16efd2df046ec92a052fa5ca93e7b
Source dataset
uspto-grants-1999_05
Patent number
US05905084

Reaction notes

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