Sodium Hydroxide → HCID 131721271, compound

HRID 1075670Notes

Reaction equation

HRID 1075670 reaction equation
C([O:3][C:4](=[O:28])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH:17]=[C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][C:19]2=[O:27])=[C:11]2[C:16]=1[N:15]=[CH:14][CH:13]=[CH:12]2)C.[OH-].[Na+:30]>O1CCOCC1>[Na+:30].[NH:20]1[C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:18](=[CH:17][C:10]2[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([O-:28])=[O:3])=[C:16]3[C:11]=2[CH:12]=[CH:13][CH:14]=[N:15]3)[C:19]1=[O:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67560836HCID 67560836, compound

Product 1

HCID 131721271HCID 131721271, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-[5-(2-oxindol-3-ylidenemethyl)quinol-8-yloxy] acetic acid ethyl ester (150 mg, 0.40 mmol) in dioxane (20 ml) was added 2N sodium hydroxide (2 ml) and the mixture was stirred for 1 h at room temperature. The resulting crystals were separated by filtration, washed with dioxane and dried. Thus pure title compound was obtained in 81.5% yield (120 mg).

Workup

  1. customThe resulting crystals were separated by filtration
  2. washwashed with dioxane
  3. customdried

Sources & evidence

ORD record
ord-c62aae3454644ea6b820897c8c386dc1
Source dataset
uspto-grants-1999_05
Patent number
US05905149

Reaction notes

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