反应详情

To a solution of 5-t-butoxycarbonylamino-2-oxindole (630 mg, 2.5 mmol) and 8-hydroxyquinoline-5-carbaldehyde (450 mg, 2.6 mmol) in absolute alcohol was added piperidine (0.26 g, 2.6 mmol). The reaction was carried out at 80° C. for 3 h. The solvent was evaporated and the residue was purified by silica gel chromatography (eluant cyclohexane/ethylacetate 2:3) thus giving 800 mg of 5-(t-butoxycarbonylamino)-3-(8-hydroxyquinol-5-ylmethylen)-2-oxindole.

1. customThe solvent was evaporated
2. customthe residue was purified by silica gel chromatography (eluant cyclohexane/ethylacetate 2:3)