HCID 131721274, compound → HCID 131721273, compound

HRID 1075684Notes

Reaction equation

HRID 1075684 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH2:17]([CH2:19][NH2:20])[OH:18].[C:21]([O-:38])(=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]>[Pd].C(O)C>[NH2:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH2:17]([CH2:19][NH2:20])[OH:18].[C:21]([O-:38])(=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]

Participants

4

Reactant 1

HCID 131721274HCID 131721274, compound

Product 1

HCID 131721273HCID 131721273, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Alanine-Ethanolamine-palmitate (AEP) was prepared by hydrogenation of Z-Ala-Ethanolamine-palmitate in a Parr hydrogenator in the presence of palladium on charcoal (10%) in ethanol. The removal of the benzyloxycarbonyl group was monitored by HPLC (System B). After removing the catalyst by filtration and evaporation of the solvent the title compound was obtained in quantitative yield.

Workup

  1. customThe removal of the benzyloxycarbonyl group
  2. customAfter removing the catalyst
  3. filtrationby filtration and evaporation of the solvent the title compound
  4. customwas obtained in quantitative yield

Sources & evidence

ORD record
ord-7473f4ad173745db9fe1dca2c9fe43a7
Source dataset
uspto-grants-1999_05
Patent number
US05906922

Reaction notes

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