Dimethylamine → HCID 21540598, compound

HRID 1075729Notes

Reaction equation

HRID 1075729 reaction equation
Cl[C:2]1[C:3]([C:17]([F:20])([F:19])[F:18])=[CH:4][C:5]2[N:9]=[C:8]([CH3:10])[N:7]([CH2:11][CH3:12])[C:6]=2[C:13]=1[N+:14]([O-:16])=[O:15].[CH3:21][NH:22][CH3:23]>C(COC)OC>[CH3:21][N:22]([CH3:23])[C:2]1[C:3]([C:17]([F:20])([F:19])[F:18])=[CH:4][C:5]2[N:9]=[C:8]([CH3:10])[N:7]([CH2:11][CH3:12])[C:6]=2[C:13]=1[N+:14]([O-:16])=[O:15]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 21540596HCID 21540596, compound

Product 1

HCID 21540598HCID 21540598, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
125 °C

Procedure

A glass reaction tube was charged with 5.0g. (0.016 mole) of 6-chloro-1-ethyl-2-methyl-7-nitro-5-trifluoromethylbenzimidazole, 20 ml. of dimethoxyethane and 15 ml. of dimethylamine and then sealed. The sealed tube was maintained at 125°C. for 16 days and then opened. The contents were evaporated to dryness and the residue extracted with hot hexane, from which crystallized 3.1g. of the desired product m.p. 111°-115°C. after recrystallization from hexane.

Workup

  1. customA glass reaction tube
  2. additionwas charged with 5.0g
  3. customThe contents were evaporated to dryness
  4. extractionthe residue extracted with hot hexane, from which
  5. customcrystallized 3.1g
  6. customof the desired product m.p. 111°-115°C. after recrystallization from hexane

Sources & evidence

ORD record
ord-7537a632f3444bdabc65c7b409f3e179
Source dataset
uspto-grants-1976_05
Patent number
US03954438

Reaction notes

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