反应详情

The 5-acetamido-1-hydroxynaphthalene-2-sulfonamide was prepared by dissolving 10.8 g. of 5-acetamido-1-acetoxynaphthalene-2-sulfonyl chloride in 10 ml. dry chloroform and heating on the steam bath with 25.0 g. anhydrous ammonium carbonate for 2.5 hours. The yellow-brown solid was dissolved by heating with 50 ml. water on the steam bath for 4 hours. Acidification with dilute hydrochloric acid to pH 5 caused the sulfonamide to precipitate. It was filtered off, washed and dried, yielding 5.61 g. (63%).

1. dissolutionby dissolving 10.8 g
2. dissolutionThe yellow-brown solid was dissolved
3. temperatureby heating with 50 ml
4. customto precipitate
5. filtrationIt was filtered off
6. washwashed
7. customdried
8. customyielding 5.61 g