Chlorotrimethylsilane → 1,2,4-Triazine, 3,5-bis[(trimethylsilyl)oxy]-

HRID 1075764Notes

Reaction equation

HRID 1075764 reaction equation
[NH:1]1[N:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[CH3:9][Si:10]([CH3:13])([CH3:12])Cl>C(N(CC)CC)C>[CH3:9][Si:10]([CH3:13])([CH3:12])[O:3][C:2]1[N:1]=[N:8][CH:7]=[C:5]([O:6][Si:10]([CH3:13])([CH3:12])[CH3:9])[N:4]=1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 680371,2,4-Triazine-3,5(2H,4H)-dione

Product 1

HCID 870571,2,4-Triazine, 3,5-bis[(trimethylsilyl)oxy]-

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In accordance with the invention, it has further been discovered that the silylation of 6-azauracil with trimethylchlorosilane and triethylamine affords an almost quantitative yield of the required 3,5-bis-trimethylsilyloxy-1,2,4-triazine in pure form when the reaction is carried out in the higher-boiling toluene and when a longer reaction period of time is used.

Sources & evidence

ORD record
ord-d8dc00f66d064dec8964a8286ae0c284
Source dataset
uspto-grants-1976_05
Patent number
US03954752

Reaction notes

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