反应详情

A solution of 10 g. (0.065 mol) of methyl 2-aminopyrazine-3-carboxylate in 100 ml. of methanol and 25 ml. of pyrrolidine was refluxed for 18 hours. The residue obtained after evaporation under reduced pressure was triturated with ether to yield 8.8 g. (70%) of the above-named product as yellow crystals, with m.p. 100°-105°. A second crop of 2.3 g. (18%) with m.p. 95°-105° was obtained from the mother liquors. The analytical sample was recrystallized from 2-propanol. The pale yellow prisms had a melting point of 104°-106°.

1. customThe residue obtained
2. customafter evaporation under reduced pressure
3. customwas triturated with ether
4. customto yield 8.8 g
5. custom(18%) with m.p. 95°-105° was obtained from the mother liquors
6. customThe analytical sample was recrystallized from 2-propanol