Pyrrolidine → HCID 54164581, compound

HRID 1075768Notes

Reaction equation

HRID 1075768 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10]C)=O)=[N:6][C:5]([Cl:12])=[CH:4][N:3]=1.[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>CO>[NH2:1][C:2]1[C:7]([C:8]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[O:10])=[N:6][C:5]([Cl:12])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 824637Methyl 3-amino-6-chloropyrazine-2-carboxylate

Product 1

HCID 54164581HCID 54164581, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2-amino-5-chloropyrazine-3-carboxylate was treated as described in Example 1 with 25 ml. of pyrrolidine in 100 ml. of methanol. Crystallization from ether yielded 7 g. (72%) of the above-named product with m.p. 90°-95°. Recrystallization from 2-propanol gave pale yellow needles with m.p. 95°-97°.

Workup

  1. customCrystallization from ether
  2. customyielded 7 g
  3. customRecrystallization from 2-propanol
  4. customgave pale yellow needles with m.p. 95°-97°

Sources & evidence

ORD record
ord-a48ebb561621468080421c9f416dbcac
Source dataset
uspto-grants-1976_05
Patent number
US03954753

Reaction notes

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