HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 21541156, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | (3-Amino-6-chloro-2-pyrazinyl)phenylmethanone | HCID 21541161 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21541156 | HCID 21541156 | — |
Reaction Steps
2-Amino-3-benzoyl-5-chloropyrazine (0.9 g or 4 mmol) was reacted as described in Example 5 with 8.1 g. (0.04 mol) of 2-bromoacetyl bromide in 25 ml. methylene chloride and 25 ml. of 10% aqueous sodium carbonate solution. The same work up yielded 1 g. (71%) of the above-named product with a melting point of 120°-125° dec. Recrystallization from methylene chloride/petroleum ether afforded colorless needles with a melting point of 124°-126° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03954753 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-68ad7f5bf4c0432380c8c2ec0caf6e2d |
| Source note | uspto-grants-1976_05 |