Sodium Carbonate → HCID 21541156, compound

HRID 1075772Notes

Reaction equation

HRID 1075772 reaction equation
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:6][C:5]([Cl:16])=[CH:4][N:3]=1.[Br:17][CH2:18][C:19](Br)=[O:20].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[C:8]([C:7]1[C:2]([NH:1][C:19](=[O:20])[CH2:18][Br:17])=[N:3][CH:4]=[C:5]([Cl:16])[N:6]=1)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 61147Bromoacetyl bromideHCID 21541161(3-Amino-6-chloro-2-pyrazinyl)phenylmethanone

Product 1

HCID 21541156HCID 21541156, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Amino-3-benzoyl-5-chloropyrazine (0.9 g or 4 mmol) was reacted as described in Example 5 with 8.1 g. (0.04 mol) of 2-bromoacetyl bromide in 25 ml. methylene chloride and 25 ml. of 10% aqueous sodium carbonate solution. The same work up yielded 1 g. (71%) of the above-named product with a melting point of 120°-125° dec. Recrystallization from methylene chloride/petroleum ether afforded colorless needles with a melting point of 124°-126° dec.

Workup

  1. customThe same work up yielded 1 g
  2. customRecrystallization from methylene chloride/petroleum ether afforded colorless needles with a melting point of 124°-126° dec.

Sources & evidence

ORD record
ord-68ad7f5bf4c0432380c8c2ec0caf6e2d
Source dataset
uspto-grants-1976_05
Patent number
US03954753

Reaction notes

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