反应详情

2-Amino-3-benzoyl-5-chloropyrazine (0.9 g or 4 mmol) was reacted as described in Example 5 with 8.1 g. (0.04 mol) of 2-bromoacetyl bromide in 25 ml. methylene chloride and 25 ml. of 10% aqueous sodium carbonate solution. The same work up yielded 1 g. (71%) of the above-named product with a melting point of 120°-125° dec. Recrystallization from methylene chloride/petroleum ether afforded colorless needles with a melting point of 124°-126° dec.

1. customThe same work up yielded 1 g
2. customRecrystallization from methylene chloride/petroleum ether afforded colorless needles with a melting point of 124°-126° dec.