Iodine → HCID 12934766, compound

HRID 1075790Notes

Reaction equation

HRID 1075790 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[NH:10]1[CH2:15][CH2:14][CH2:13][N:12]=[C:11]1[SH:16].[I:17]I.[I-].[K+]>CO.O>[IH:17].[NH:12]1[CH2:13][CH2:14][CH2:15][N:10]=[C:11]1[S:16][C:3]1[C:4]2[C:9](=[N:8][CH:7]=[CH:6][CH:5]=2)[NH:1][CH:2]=1

Participants

7

Reactant 4

HCID 807IodineHCID 4875Potassium IodideHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 178527864HCID 178527864, compound

Product 1

HCID 12934766HCID 12934766, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

A mixture of 2.8 g 7-azaindole in 25 ml methanol and 3.5 g 1,4,5,6-tetrahydro-2-pyrimidinethiol in 50 ml methanol is added to a well-stirred solution of 7.6 g iodine and 15 g potassium iodide in 50 ml water. The mixture is stirred at room temperature for 14 hours and filtered. The precipitate is washed with water and ether and then recrystallised from water to give 3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-7-aza-indole hydriodide melting at 294°-295°.

Workup

  1. filtrationfiltered
  2. washThe precipitate is washed with water and ether
  3. customrecrystallised from water

Sources & evidence

ORD record
ord-7dc4e91b4680473db12e5eb0494f0eea
Source dataset
uspto-grants-1976_05
Patent number
US03954757

Reaction notes

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