Iodine → HCID 12934713, compound

HRID 1075796Notes

Reaction equation

HRID 1075796 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[I-:11].[K+].II.[NH:15]1[CH2:20][CH2:19][CH2:18][N:17]=[C:16]1[SH:21]>CO.O>[IH:11].[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[S:21][C:16]1[NH:17][CH2:18][CH2:19][CH2:20][N:15]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

Participants

7

Reactant 4

HCID 807IodineHCID 4875Potassium IodideHCID 72242-MethylindoleHCID 178527864HCID 178527864, compound

Product 1

HCID 12934713HCID 12934713, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

A solution of 19.65 g of 2-methylindole in 250 ml of methanol is added to a well-stirred solution of 75 g of potassium iodide and 38 g of iodine in 225 ml of water at room temperature. This mixture is further treated with a solution of 17.4 g of 1,4,5,6-tetrahydro-2-pyrimidinethiol in 350 ml of warm methanol, stirred for 2 hours and worked up in the manner described under Example 1 to yield 2-methyl-3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole hydriodide which melts at 242° after recrystallization from a mixture of methanol and ethyl acetate.

Sources & evidence

ORD record
ord-357c1217e5ce40dea6328614b6065c57
Source dataset
uspto-grants-1976_05
Patent number
US03954757

Reaction notes

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