5-Fluorodihydro-6-hydroxy-2,4-(1H,3H)-pyrimidinedione → 5-Fluorouracil

HRID 1075810Notes

Reaction equation

HRID 1075810 reaction equation
[F:1][CH:2]1[CH:7](O)[NH:6][C:5](=[O:9])[NH:4][C:3]1=[O:10].FC1C(OC(C)C)NC(=O)NC1=O>>[F:1][C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:9])[NH:6][CH:7]=1

Participants

3

Reactant 2

HCID 36505-Fluorodihydro-6-hydroxy-2,4-(1H,3H)-pyrimidinedioneHCID 12829550HCID 12829550, compound

Product 1

HCID 33855-Fluorouracil

Procedure

Example 15 was repeated, using 5-fluoro-6-hydroxy-5,6-dihydrouracil obtained in Example 5 for the 5-fluoro-6-isopropoxy-5,6-dihydrouracil. 5-fluorouracil was obtained as the product.

Sources & evidence

ORD record
ord-739bf73c10454cbc87fc37f11ce62ef5
Source dataset
uspto-grants-1976_05
Patent number
US03954759

Reaction notes

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