1-Methylpiperazine → HCID 21541237, compound

HRID 1075826Notes

Reaction equation

HRID 1075826 reaction equation
Cl[CH:2]1[C:8]2[CH:9]=[C:10]([S:13][CH3:14])[CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:4]=2[CH2:3]1.[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(Cl)(Cl)Cl>[CH3:19][C:16]1[CH:17]=[CH:18][C:4]2[CH2:3][CH:2]([N:24]3[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]3)[C:8]3[CH:9]=[C:10]([S:13][CH3:14])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=2[CH:15]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 21416153HCID 21416153, compound

Product 1

HCID 21541237HCID 21541237, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

10.0 G. of 10-chloro-10,11-dihydro-3-methyl-8-methylthio-dibenzo[b,f]thiepin, 300 ml. of chloroform and 9.8 g. of N-methylpiperazine are heated at reflux for 30 hours. The mixture is evaporated under reduced pressure. The residue is worked up in an analogous manner to that described in Example 1, and there is obtained 1-(10,11-dihydro-3-methyl-8-methylthio-dibenzo[b,f]-thiepin-10-yl)-4-methylpiperazine whose dimethanesulfonate crystallizes from acetone and melts at 199°-200°C.

Workup

  1. temperatureat reflux for 30 hours
  2. customThe mixture is evaporated under reduced pressure

Sources & evidence

ORD record
ord-e8c5ec870f414cbf85997f172abaaf1a
Source dataset
uspto-grants-1976_05
Patent number
US03954769

Reaction notes

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