Sodium Hydroxide → 56915-77-6

HRID 1075828Notes

Reaction equation

HRID 1075828 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[OH-].[Na+]>O>[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8](=[O:10])[CH3:9])[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 531671-MethylpiperazineHCID 96744o-Fluoroacetophenone

Product 1

HCID 2140456756915-77-6

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 55.2 g. of o-fluoroacetophenone and 100 ml. of N-methyl-piperazine is heated at 95°-100° for 19 hours, then cooled and poured into 1600 ml. of water containing 22 ml. of 50% aqueous sodium hydroxide. The mixture is extracted with three 300 ml. portions of ether. The combined ether extract is washed thoroughly with water, then with saturated aqueous sodium chloride, dried and evaporated to give o-(4-methyl-1-piperazinyl)acetophenone as a viscous oil, suitable for use without further purification.

Workup

  1. additionA mixture of 55.2 g
  2. temperaturecooled
  3. additionpoured into 1600 ml
  4. extractionThe mixture is extracted with three 300 ml
  5. extractionThe combined ether extract
  6. washis washed thoroughly with water
  7. dry with materialwith saturated aqueous sodium chloride, dried
  8. customevaporated

Sources & evidence

ORD record
ord-fe8457fe8bd345579b1089efa0b6cc38
Source dataset
uspto-grants-1976_05
Patent number
US03954734

Reaction notes

Loading…