Phosphorus pentachloride → HCID 21402903, compound

HRID 1075858Notes

Reaction equation

HRID 1075858 reaction equation
[Cl:1][C:2]1[S:3][C:4]2[C:13]([N:14]=1)=[CH:12][CH:11]=[C:10]1[C:5]=2[C:6](O)=[C:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:8]=[N:9]1.P(Cl)(Cl)(Cl)(Cl)[Cl:22]>P(Cl)(Cl)(Cl)=O>[Cl:1][C:2]1[S:3][C:4]2[C:13]([N:14]=1)=[CH:12][CH:11]=[C:10]1[C:5]=2[C:6]([Cl:22])=[C:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:8]=[N:9]1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 178469495HCID 178469495, compound

Product 1

HCID 21402903HCID 21402903, compound

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

A mixture of 3.09 g of ethyl 2-chloro-9-hydroxythiazolo[5,4-f]quinoline-8-carboxylate, 20 ml of phosphorus oxychloride and 0.2 g of phosphorus pentachloride was refluxed for 1 hour and the reaction mixture was treated in the same manner as described in Example 5 to give ethyl 2,9-dichlorothiazolo[5,4-f]quinoline8-carboxylate.

Workup

  1. temperaturewas refluxed for 1 hour
  2. additionthe reaction mixture was treated in the same manner

Sources & evidence

ORD record
ord-1eec30edcd324918a32ac5b292aaec44
Source dataset
uspto-grants-1976_05
Patent number
US03954775

Reaction notes

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