Hydrazine hydrate (1:1) → HCID 12582695, compound

HRID 1075905Notes

Reaction equation

HRID 1075905 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:27])[CH2:13][CH:14]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][C:4]=2[CH:3]=1.O.[NH2:29][NH2:30]>O1CCOCC1>[C:15]1([CH:14]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:13][C:12]([N:10]2[CH2:9][CH2:8][C:5]3[N:6]=[N:7][C:2]([NH:29][NH2:30])=[CH:3][C:4]=3[CH2:11]2)=[O:27])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 204415933-Chloro-6-(3,3-diphenylpropionyl)-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine

Product 1

HCID 12582695HCID 12582695, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

7.6 g of 3-chloro-6-(3,3-diphenylpropionyl)-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine in 40 cc of hydrazine hydrate and 40 cc of dioxane are stirred at a bath temperature of 100° during 12 hours. The mixture is cooled with ice, whereupon the title compound precipitates and is recrystallized from ethanol/water (ratio 6:1). The title compound has a M.P. of 208°-211° (decomp.).

Sources & evidence

ORD record
ord-0f21c8f61b9948eb8883dc5d090f8065
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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