Hydrazine hydrate (1:1) → HCID 12582641, compound

HRID 1075916Notes

Reaction equation

HRID 1075916 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:11][C:4]=2[CH:3]=1.O.[NH2:19][NH2:20]>>[NH:19]([C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:11][C:4]=2[CH:3]=1)[NH2:20]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20441586HCID 20441586, compound

Product 1

HCID 12582641HCID 12582641, compound

Procedure

11.4 g of 3-chloro-5,6,7,8-tetrahydro-6-pivaloylpyrido[4,3-c]pyridazine and 100 cc of hydrazine hydrate are boiled at reflux at a bath temperature of 110° for 11/2 hours while stirring. The crude title compound is taken up in 100 cc of chloroform, is dried with sodium sulphate, the chloroform solution is again concentrated, and recrystallized from 20 cc of absolute ethanol. The title compound has a M.P. of 158°-160° (decomp.).

Workup

  1. temperatureat reflux at a bath temperature of 110° for 11/2 hours

Sources & evidence

ORD record
ord-1d21ef601a784e218f5f3cee5b198232
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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