2,5-Dihydroxybenzoic acid → HCID 12582647, compound

HRID 1075918Notes

Reaction equation

HRID 1075918 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:11][C:4]=2[CH:3]=1.O.[NH2:22][NH2:23].C1C(O)=CC(C(O)=O)=C(O)C=1>O1CCOCC1>[NH:22]([C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:11][C:4]=2[CH:3]=1)[NH2:23]

Participants

5

Reactant 3

HCID 34692,5-Dihydroxybenzoic acidHCID 24654Hydrazine hydrate (1:1)HCID 20441552HCID 20441552, compound

Product 1

HCID 12582647HCID 12582647, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

11.5 g of 3-chloro-6-octanoyl-5,6,7,8-tetrahydropyrido(4,3-c]pyridazine, dissolved in 50 cc of dioxane, and 30 cc of hydrazine hydrate are stirred at a bath temperature of 100° for 16 hours, and the mixture is worked up as described in Example 17. The gentisinate of the title compound has a M.P. of 164°-166° (decomp., from methanol).

Sources & evidence

ORD record
ord-e28d9c743f504cbdaf865788ee89a980
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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