Hydrazine hydrate (1:1) → Pyrido(4,3-c)pyridazine-6(5H)-carboxylic acid, 7,8-dihydro-3-hydrazino-, ethyl ester

HRID 1075921Notes

Reaction equation

HRID 1075921 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:16][CH2:15][C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:8]=2[CH2:7]1)=[O:5])[CH3:2].O.[NH2:18][NH2:19]>>[CH2:1]([O:3][C:4]([N:6]1[CH2:16][CH2:15][C:9]2[N:10]=[N:11][C:12]([NH:18][NH2:19])=[CH:13][C:8]=2[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12582766Ethyl 3-chloro-7,8-dihydropyrido[4,3-c]pyridazine-6(5H)-carboxylate

Product 1

HCID 217824Pyrido(4,3-c)pyridazine-6(5H)-carboxylic acid, 7,8-dihydro-3-hydrazino-, ethyl ester

Procedure

113 g of 3-chloro-5,6,7,8-tetrahydro-6-pyrido[4,3-c]pyridazinecarboxylic acid ethyl ester and 470 cc of hydrazine hydrate are stirred at reflux at a bath temperature of 110° for 1 hour. The title compound has a M.P. of 145°-147° (decomp., from absolute ethanol).

Workup

  1. temperatureat reflux at a bath temperature of 110° for 1 hour

Sources & evidence

ORD record
ord-7bbb9d940b0e46238776ddfafd61ede6
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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