Hydrazine hydrate (1:1) → HCID 12582638, compound

HRID 1075924Notes

Reaction equation

HRID 1075924 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:21][CH2:20][C:14]2[N:15]=[N:16][C:17](Cl)=[CH:18][C:13]=2[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:23][NH2:24]>>[CH2:1]([O:8][C:9]([N:11]1[CH2:21][CH2:20][C:14]2[N:15]=[N:16][C:17]([NH:23][NH2:24])=[CH:18][C:13]=2[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54479689Phenylmethyl 3-chloro-7,8-dihydropyrido[4,3-c]pyridazine-6(5H)-carboxylate

Product 1

HCID 12582638HCID 12582638, compound

Procedure

19.2 g of crude oily 3-chloro-5,6,7,8-tetrahydro-6-pyrido[4,3-c]pyridazinecarboxylic acid benzyl ester and 100 cc of hydrazine hydrate are stirred at a bath temperature of 70° for 71/2 hours, and the mixture is worked up to the crude title compound in a manner analogous to that described in Example 37, and this compound is recrystallized from acetonitrile. M.P. 135°-137° (decomp.).

Sources & evidence

ORD record
ord-5cf5af1a5e6e4846bdce72d8f2c46fec
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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