Ethyl Bromide → Pyrido(4,3-c)pyridazine-6(5H)-carboxylic acid, 7,8-dihydro-3-hydrazino-, ethyl ester

HRID 1075926Notes

Reaction equation

HRID 1075926 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:18][CH2:17][C:9]2[N:10]=[N:11][C:12](SCC)=[CH:13][C:8]=2[CH2:7]1)=[O:5])[CH3:2].C(OC(N1CCC2[N:28]=[N:29]C(S)=CC=2C1)=O)C.C(Br)C>>[CH2:1]([O:3][C:4]([N:6]1[CH2:18][CH2:17][C:9]2[N:10]=[N:11][C:12]([NH:28][NH2:29])=[CH:13][C:8]=2[CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 6332Ethyl BromideHCID 54200117HCID 54200117, compoundHCID 178473320HCID 178473320, compound

Product 1

HCID 217824Pyrido(4,3-c)pyridazine-6(5H)-carboxylic acid, 7,8-dihydro-3-hydrazino-, ethyl ester

Procedure

The 3-ethylmercapto-5,6,7,8-tetrahydro-6-pyrido[4,3-c]pyridazinecarboxylic acid ethyl ester, required as starting material, may be obtained in a manner analogous to that described in Example 41 (b), from 5,6,7,8-tetrahydro-3-mercapto-6-pyrido[4,3-c]pyridazinecarboxylic acid ethyl ester and ethyl bromide. M.P. 54°-56° from ligroin.

Workup

  1. custommay be obtained in a manner analogous to

Sources & evidence

ORD record
ord-5c19345fabc040b19af6eedc111bafd5
Source dataset
uspto-grants-1976_05
Patent number
US03954754

Reaction notes

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