反应详情

温度

135 °C

1.5 mols of benzimidazolone (201.2 g) are dissolved in 1.5 liters of N,N-dimethylacetamide at 120°C and 2.5 g of lithium chloride are added. 244.2 g (3.3 mols) of glycerol glycide (glycidol) are added dropwise over the course of 2 hours to this solution. The solution is then stirred for a further 5 hours at 135°C. After bringing the solution to room temperature, it is filtered and completely concentrated. The residue is dried for a further 5 hours at 95°C under 0.8 mm Hg. This gives 448 g of a brownish, very viscous liquid (theoretical yield: 423.5 g) which is the crude product still contaminated with a little dimethylacetamide.

1. customto room temperature
2. filtrationit is filtered
3. concentrationcompletely concentrated
4. customThe residue is dried for a further 5 hours at 95°C under 0.8 mm Hg