反应详情

A solution of m-chloroperbenzoic acid (2.03 g) in chloroform (30 ml) was added dropwise to a solution of 2,2,2-trichloroethyl-2-chloromethyl-2-methyl-6-(2-phenylacetamido)penam-3-carboxylate (5.0 g) in chloroform (40 ml) at -10° ~ -5°C under stirring, and then the mixture was stirred at -10° ~ -5°C for 1 hour. After the solid was filtered off, the filtrate was washed with a saturated sodium becarbonate aqueous solution and water, in turn, and then dried over magnesium sulfate. After removal of solvent, the residue was crystallized by adding ethanol. The crystal was filtered and recrystallized from ethanol to give 2,2,2-trichloroethyl 2-chloromethyl-2-methyl-6-(2-phenylacetamido)penam-3-carboxylate-1-oxide (4.10 g), mp 130° ~ 131°C.

1. stirringthe mixture was stirred at -10° ~ -5°C for 1 hour
2. filtrationAfter the solid was filtered off
3. washthe filtrate was washed with a saturated sodium becarbonate aqueous solution and water, in turn
4. dry with materialdried over magnesium sulfate
5. customAfter removal of solvent
6. customthe residue was crystallized
7. additionby adding ethanol
8. filtrationThe crystal was filtered
9. customrecrystallized from ethanol