HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-Hydroxy-3-(4'-chloro-4-biphenylyl)-3-p-chlorophenylpropionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | 4'-Chloro-4-biphenylyl 4-chlorophenyl ketone | HCID 20363844 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-Hydroxy-3-(4'-chloro-4-biphenylyl)-3-p-chlorophenylpropionitrile | HCID 53831390 | — |
Reaction Steps
4'-Chloro-4-biphenylyl 4-chlorophenyl ketone (16.4 g.) and acetonitrile (2.25 g.) were reacted in benzene in the presence of sodamide (2.5 g.) by the method of Lettre and Wick (Annalen, 1957, 603, 194) to give 3-hydroxy-3-(4'-chloro-4-biphenylyl)-3-p-chlorophenylpropionitrile, m.p. 123°C after recrystallisation from benzene; λ max (ethanol) = 260 nm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03954869 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-04b0fbbffc864ba38db4b678f9571588 |
| Source note | uspto-grants-1976_05 |