反应详情

4'-Chloro-4-biphenylyl 4-chlorophenyl ketone (16.4 g.) and acetonitrile (2.25 g.) were reacted in benzene in the presence of sodamide (2.5 g.) by the method of Lettre and Wick (Annalen, 1957, 603, 194) to give 3-hydroxy-3-(4'-chloro-4-biphenylyl)-3-p-chlorophenylpropionitrile, m.p. 123°C after recrystallisation from benzene; λ max (ethanol) = 260 nm.