Acetaldehyde → HCID 21541740, compound

HRID 1076097Notes

Reaction equation

HRID 1076097 reaction equation
[P:1]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[O:2]C1C=CC=CC=1.[CH:23](=O)[CH3:24].[O:26]1[CH2:31][CH2:30][N:29]([S:32]([NH2:35])(=[O:34])=[O:33])[CH2:28][CH2:27]1.ClC1C=CC=CC=1>CCOCC>[O:26]1[CH2:31][CH2:30][N:29]([S:32]([NH:35][CH:23]([P:1](=[O:2])([O:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH3:24])(=[O:34])=[O:33])[CH2:28][CH2:27]1

Participants

6

Reactant 4

HCID 177AcetaldehydeHCID 7540Triphenyl phosphiteHCID 7964ChlorobenzeneHCID 2767394-Morpholinesulfonamide

Product 1

HCID 21541740HCID 21541740, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 0.15 mole each of triphenyl phosphite, acetaldehyde, and morpholinosulfonylamine in 100g of chlorobenzene is warmed at 100°C. for 1.25 hrs, and the reaction mixture is stripped to 110°/0.15mm. The cooled residue is diluted with 100ml of ether, causing separation of 34.5g of crude solid product. Recrystallization of a portion from isopropyl alcohol gives a white solid, mp 104.5°-108°, 31 p nmr(DMSO-d6) -18.1 ppm.

Workup

  1. customis stripped to 110°
  2. customseparation of 34.5g of crude solid product
  3. customRecrystallization of a portion from isopropyl alcohol
  4. customgives a white solid, mp 104.5°-108°, 31 p nmr(DMSO-d6) -18.1 ppm

Sources & evidence

ORD record
ord-7ff4a440ab554e84a6998bb643450b56
Source dataset
uspto-grants-1976_05
Patent number
US03954860

Reaction notes

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