2-Nitrophenol → 4-Nitrophenol

HRID 1076099Notes

Reaction equation

HRID 1076099 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1O)([O-:3])=[O:2].S([O-])([O-])=[O:12].[Na+].[Na+]>>[CH:9]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=1

Participants

3

Reactant 2

HCID 69472-Nitrophenol2×HCID 24437Sodium Sulfite

Product 1

HCID 9804-Nitrophenol

Procedure

The pH of the aqueous distillation residue can be adjusted by addition of acid or alkali. According to a preferred procedure, the slightly acid organic solution containing the nitrophenol isomers is neutralised by means of an aqueous solution of sodium sulphite the solvent followed by the o-nitrophenol are then removed to leave a slightly alkaline aqueous distillation residue of p-nitrophenol, to which a suitable amount of acid is added to adjust the pH. The acid may be a strong inorganic acid such as sulphuric acid or phosphoric acid or an organic acid such as acetic acid. The pH is preferably adjusted to 5.8 to 6.1 but in practice, it is very particularly recommended to adjust the pH of the aqueous solution of para-nitrophenol to pH 6.

Workup

  1. additionThe pH of the aqueous distillation residue can be adjusted by addition of acid
  2. customare then removed

Sources & evidence

ORD record
ord-381bcb72520d4abfb8d99d7459e8821c
Source dataset
uspto-grants-1976_05
Patent number
US03954892

Reaction notes

Loading…