Propylene Glycol → HCID 178512755, compound

HRID 1076124Notes

Reaction equation

HRID 1076124 reaction equation
[CH:1]1[C:2](/[CH:8]=[N:9]/[NH:10][C:11]([NH:13]/[N:14]=[CH:15]/[C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:12])=[CH:3][CH:4]=[C:5]([Cl:7])[CH:6]=1.Cl.C(O)C(O)C>>[CH:17]1[C:16](/[CH:15]=[N:14]/[NH:13][C:11]([NH:10]/[N:9]=[CH:8]/[C:2]2[CH:3]=[CH:4][C:5]([Cl:7])=[CH:6][CH:1]=2)=[NH:12])=[CH:21][CH:20]=[C:19]([Cl:22])[CH:18]=1

Participants

3

Reactant 2

HCID 1030Propylene GlycolHCID 178479420HCID 178479420, compound

Product 1

HCID 178512755HCID 178512755, compound

Procedure

500 mg of finely pulverized Robenidine HCl was introduced to a previously melted 10 g of polyoxy ethylene triglyceride (Arlatone 289 - Atlas Corp.) The mixture was heated and stirred at 60°-80° until a fine paste was obtained. 66.6 ml of a solution prepared from 75 ml of polyethylene glycol (Carbowax 300) and 25 ml of propylene glycol was added and the mixture was stirred and heated at 60°-80° until a clear solution was obtained. After cooling to room temperature the solution was filtered. The solution had a concentration of 0.65 g of Robenidine HCl. 2.3 ml of said composition in 1 L of water yielded a concentration of 30 mg of Robenidine/ 1 L of water.

Workup

  1. temperaturewas heated
  2. customwas obtained
  3. additionwas added
  4. stirringthe mixture was stirred
  5. temperatureheated at 60°-80° until a clear solution
  6. customwas obtained
  7. filtrationwas filtered

Sources & evidence

ORD record
ord-1748a760ed3b4c54aebbfc4350052599
Source dataset
uspto-grants-1976_05
Patent number
US03954996

Reaction notes

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