Sodium Bicarbonate → HCID 6604391, compound

Participants

Reaction Steps

To a vigorously stirred solution of pivampicillin hydrochloride (10 g) in water (50 ml) and diethyl ether (3.5 ml) was added a solution of sodium bicarbonate (2 g) in water (20 ml). The addition was complete after 20-30 min. and the mixture was allowed to stir for further 30 min. The crystalline product was filtered off, washed with water (60 ml) and diethyl ether (20 ml), and air-dried to yield pivampicillin with a melting point 114°-116° C.

Provenance & Evidence