Sodium Bicarbonate → HCID 6604391, compound

HRID 1076161Notes

Reaction equation

HRID 1076161 reaction equation
[CH3:1][C:2]1([CH3:32])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([O:23][CH2:24][O:25][C:26]([C:28]([CH3:31])([CH3:30])[CH3:29])=[O:27])=[O:22].Cl.C(=O)(O)[O-].[Na+]>O.C(OCC)C>[CH3:1][C:2]1([CH3:32])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@@H:13]([NH2:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([O:23][CH2:24][O:25][C:26]([C:28]([CH3:31])([CH3:30])[CH3:29])=[O:27])=[O:22]

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 76313488HCID 76313488, compound

Product 1

HCID 6604391HCID 6604391, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

To a vigorously stirred solution of pivampicillin hydrochloride (10 g) in water (50 ml) and diethyl ether (3.5 ml) was added a solution of sodium bicarbonate (2 g) in water (20 ml). The addition was complete after 20-30 min. and the mixture was allowed to stir for further 30 min. The crystalline product was filtered off, washed with water (60 ml) and diethyl ether (20 ml), and air-dried to yield pivampicillin with a melting point 114°-116° C.

Workup

  1. additionThe addition
  2. filtrationThe crystalline product was filtered off
  3. washwashed with water (60 ml) and diethyl ether (20 ml)
  4. customair-dried

Sources & evidence

ORD record
ord-7ee58a992c9f47e998bc082723ecd9bd
Source dataset
uspto-grants-1976_05
Patent number
US03956279

Reaction notes

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