反应详情

The starting 11β-formyloxy-androst-4-ene-3,17-dione was prepared from 11β-hydroxy-androst-4-ene-3,17-dione by dissolving the latter in excess formic acid in the presence of a catalytic amount of perchloric acid and, after 20 hours at room temperature, pouring the reaction mixture on ice, extracting with methylene chloride and evaporating. There was obtained a product melting at 139°-139.5° (crystallized from ethyl acetate), [α]D25 = 188° (dioxane).

1. additionpouring the reaction mixture on ice
2. extractionextracting with methylene chloride
3. customevaporating