Hydrochloric Acid → 3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

HRID 107630Notes

Reaction equation

HRID 107630 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17](-[c:19]3[cH:20][n:21][c:22]([NH2:37])[c:23]([O:25][CH:26]([CH3:27])[c:28]4[c:29]([Cl:36])[c:30]([F:35])[cH:31][cH:32][c:33]4[Cl:34])[cH:24]3)[cH:18]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:45][CH2:46][Cl:47].[ClH:38].[O:39]1[CH2:40][CH2:41][O:42][CH2:43][CH2:44]1>>[NH:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17](-[c:19]3[cH:20][n:21][c:22]([NH2:37])[c:23]([O:25][CH:26]([CH3:27])[c:28]4[c:29]([Cl:36])[c:30]([F:35])[cH:31][cH:32][c:33]4[Cl:34])[cH:24]3)[cH:18]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 58659146(S)-tert-Butyl 4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 115975713-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

Sources & evidence

ORD record
ord-cfe16289a0a84f3d8342f8cb0b27e932
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…