1-[2-(Trifluoromethyl)phenyl]propan-2-amine → (+/-)-Norfenfluramine

HRID 1076353Notes

Reaction equation

HRID 1076353 reaction equation
FC(F)(F)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH:10]([NH2:12])[CH3:11].[F:15][C:16]([F:28])([F:27])C1C=CC(CC(N)C)=CC=1>>[F:15][C:16]([F:28])([F:27])[C:6]1[CH:5]=[C:4]([CH2:9][CH:10]([NH2:12])[CH3:11])[CH:3]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 1207631-[2-(Trifluoromethyl)phenyl]propan-2-amineHCID 1215021-[4-(Trifluoromethyl)phenyl]propan-2-amine

Product 1

HCID 15897(+/-)-Norfenfluramine

Procedure

According to the method used in Examples 1 to 14 but using 1-(2-trifluoromethylphenyl)-2-aminopropane, and 1-(4-trifluoromethylphenyl)-2-aminopropane, instead of 1-(3-trifluoromethylphenyl)-2-aminopropane, there were obtained the corresponding N-[1-(2-trifluoromethylphenyl) prop-2-yl] glycinates and N-[1-(4-trifluoromethylphenyl) prop-2-yl] glycinates.

Sources & evidence

ORD record
ord-3404640e641f45728c4f7cd3eb7e10ca
Source dataset
uspto-grants-1976_05
Patent number
US03956501

Reaction notes

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