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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1076353Generated: November 3, 2026

1-[2-(Trifluoromethyl)phenyl]propan-2-amine → (+/-)-Norfenfluramine

https://huagongshe.com/reaction/1076353

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[2-(Trifluoromethyl)phenyl]propan-2-amineHCID 120763—
Reactant1-[4-(Trifluoromethyl)phenyl]propan-2-amineHCID 121502—
Product(+/-)-NorfenfluramineHCID 15897—

Reaction Steps

According to the method used in Examples 1 to 14 but using 1-(2-trifluoromethylphenyl)-2-aminopropane, and 1-(4-trifluoromethylphenyl)-2-aminopropane, instead of 1-(3-trifluoromethylphenyl)-2-aminopropane, there were obtained the corresponding N-[1-(2-trifluoromethylphenyl) prop-2-yl] glycinates and N-[1-(4-trifluoromethylphenyl) prop-2-yl] glycinates.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03956501
Source datasetuspto-grants-1976_05
ORD IDord-3404640e641f45728c4f7cd3eb7e10ca
Source noteuspto-grants-1976_05